EMVI as a determinant of metastasis in colorectal cancer
IRAS Number: 288231
CPMS ID: 55248
ClinicalTrials.gov ID:
Trial Start Date: Oct-20
Recruitment End Date: Dec-26
Trial End date: Dec-28
A retrospective ,non-interventional tissue study using archival materials collected through a patient’s routine care, EVIDENCE aims to demonstrate that distant metastases in colorectal cancer are related to EMVI and tumour deposits, not lymph nodes.
We will test whether the vascular route of spread (as evidenced through EMVI and tumour deposits) is more important than lymph nodes in the development of metastatic disease. We will compare the subclonal origins of primary colorectal cancers, EMVI, tumour deposits, lymph nodes and distant metastases by reconstructing phylogenetic trees. A proof for a vascular route of spread rather than lymph nodes would lead to a paradigm shift in future decision making at national and international level.
Patients who have undergone a primary resection of their colon or rectum as well as a resection of a distant metastases are eligible. As EVIDENCE is a retrospective study, there are no time dependent schedules for CRF completion or tissue submission.