Optimum timing for surgery after pre-operative radiotherapy
In rectal cancer, radiotherapy is frequently given prior to surgery to enable complete removal and reduce recurrence. Uncertainty remains regarding the timing of surgery and a delay to 12-14 weeks has been hypothesised as advantageous.
The 6vs12 trial is a multicentre randomised clinical trial. Individuals diagnosed with rectal cancer of T3 stage and above will be identified at colorectal MDT and offered randomisation between surgery at 6-8 or 12-14 weeks following completion of radiotherapy. PET/CT, pelvic MRI and final histopathology will be used to determine the response to radiotherapy. The degree of down-staging and tumour regression at 6-8 versus 12-14 weeks will then be compared.
The 6 vs 12 trial is now closed to recruitment.
You can view and download a pdf copy of the protocol here.
Please fill in the form below if you would like further information or have any questions about any aspect of the trial.
