Concordance in MRI and Pathology Diagnosis of Extranodal Tumour Deposits
IRAS Number: 217627
CPMS ID: 35640
ClinicalTrials.gov ID: NCT03303547
Trial Start Date: Oct-17
Recruitment End Date: Dec-24
Trial End date: Nov-29
We are studying how imaging can be used to improve the accuracy of how a tumour is classified. This will give us a better understanding of how different tumours behave. We will perform the standard imaging tests and patients will have same operation. The only difference is how the bowel specimen is processed in the laboratory. We will take photographs of the bowel after it has been cut into slices and match this up with the scans.
A prospective interventional multi-centre study, COMET aims to prove the accuracy of imaging diagnosis of extranodal tumour deposits (TD) and their adverse effect on prognosis of colorectal cancers. The proposed intervention will be additional radiological and pathological assessment and the reporting of supplementary diagnostic information which would not otherwise have been available. This may affect treatment according to local MDT protocols and also affect the provision of prognostic information to patients in subsequent discussions.
Any patient with a suspected primary adenocarcinoma of the colon, sigmoid or rectum undergoing surgery are eligible. The date of surgery must be known prior to registration. This trial aims to determine if image mapping techniques can improve the concordance between imaging and pathology detection of tumour deposits. Lymph nodes and tumour deposits will be identified on pre-operative scans and mapped by radiologists then shared with pathologists prior to processing the resected specimen. Patients will be managed at their local hospital with standard follow-up. Patients will be followed up for 5 years.
The COMET trial is open for recruitment.
Please fill in the form below if you would like further information or have any questions about any aspect of the trial.