Our clinical trials are now sponsored by Imperial College London
Please click on the name of any of our trials below to find out more
Please click on the eligibility diagram to see how patients can be co-enrolled into our trials
TRIGGER – a randomised trial looking at watch and wait for patients identified using mrTRG. The trial is a non-CTIMP therefore the preoperative treatment offered is according to local practice and not determined by the trial protocol (e.g. CRT, TNT)
COMET – a study evaluating tumour deposits vs lymph nodes in patients undergoing surgery to determine the relative importance of tumour deposits vs lymph nodes in predicting prognosis.
SERENADE – a study looking at earlier detection of liver metastases in patients with EMVI or tumour deposits using liver MRI.
IMPRESS – a randomised trial testing MRI staging for pelvic sigmoid cancer compared with CT to improve surgical outcomes.
Beyond TME Origins – a study evaluating the cause and treatment of pelvic recurrence following initial treatment of primary colon and rectal cancer in the pelvis.
ctDNA – a study to determine the relationship between ctDNA and EMVI/tumour deposits in patients undergoing primary colon or rectal cancer surgery
EVIDENCE – a tissue study evaluating whether distant metastases in colorectal cancer are related to EMVI and tumour deposits, not lymph nodes
DRIVEN – a retrospective analysis of pre-operative prognostic biomarkers in resected right compared with left colon cancer, and the influence of operative approach on survival
PRESERVE – a study to determine if we can successfully introduce accurate MRI staging of early rectal cancer into MDTs in 20 NHS Trusts
MERCURY 3 – a study to determine that a different staging system of mrTDV will improve the care and survival rates of patients with rectal cancer compared with the current practice of using TNM.
TRIALS CLOSED TO RECRUITMENT